Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4842
Gene Symbol: NOS1
NOS1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.230 Therapeutic RGD [Effects of shenshuai II recipe on the protein expressions of Ang II and nNOS in chronic renal failure rats' nephridial tissue]. 23185775

2012

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.210 Biomarker RGD [Curative machanism of Shenle capsule on 5/6 nephrectomy rats]. 15506291

2004

Entrez Id: 4842
Gene Symbol: NOS1
NOS1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.230 Biomarker RGD Vitamin E reduces glomerulosclerosis, restores renal neuronal NOS, and suppresses oxidative stress in the 5/6 nephrectomized rat. 17200156

2007

Entrez Id: 3667
Gene Symbol: IRS1
IRS1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Vascular insulin resistance related to endoplasmic reticulum stress in aortas from a rat model of chronic kidney disease. 22942179

2012

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Vascular insulin resistance related to endoplasmic reticulum stress in aortas from a rat model of chronic kidney disease. 22942179

2012

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.300 Biomarker RGD Urine levels of NOx and the expression of glomerular eNOS and tubulointerstitial nNOS were significantly decreased in CRF rats compared with normal rats. 18089446

2008

Entrez Id: 1191
Gene Symbol: CLU
CLU
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.210 Biomarker RGD Urinary biomarkers track the progression of nephropathy in hypertensive and obese rats. 24325231

2014

Entrez Id: 5741
Gene Symbol: PTH
PTH
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.300 Biomarker RGD Two novel vitamin D receptor modulators with similar structures exhibit different hypercalcemic effects in 5/6 nephrectomized uremic rats. 23548814

2013

Entrez Id: 5734
Gene Symbol: PTGER4
PTGER4
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Therapeutic RGD Thus, agonism of EP2 and EP4 receptors may provide a basis for treating acute and chronic kidney failure. 16871242

2006

Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD This study attempted to determine the effects of CRF on liver P450 isoforms and NAT2 expressions by using a CRF mouse model. 20007296

2010

Entrez Id: 9365
Gene Symbol: KL
KL
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.300 Biomarker RGD This is the first report showing the expression of the klotho gene in the kidney is regulated under sustained circulatory stress such as long-term hypertension, diabetes mellitus, and chronic renal failure. 9731228

1998

Entrez Id: 4973
Gene Symbol: OLR1
OLR1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD These results suggest that enhanced renal expression of LOX-1 might play some roles in the progression of chronic renal failure in rats. 12661921

2003

Entrez Id: 5741
Gene Symbol: PTH
PTH
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.300 Biomarker RGD The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response to phosphate binders in the rat. 21826734

2011

Entrez Id: 6569
Gene Symbol: SLC34A1
SLC34A1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.300 Biomarker RGD The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response to phosphate binders in the rat. 21826734

2011

Entrez Id: 8435
Gene Symbol: SOAT2
SOAT2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD The CRF animals showed a significant reduction in creatinine clearance, marked hypertriglyceridemia, modest hypercholesterolemia, and significant upregulation of hepatic tissue ACAT-2 protein and mRNA abundance. 12217884

2002

Entrez Id: 26762
Gene Symbol: HAVCR1
HAVCR1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.240 Biomarker RGD Structural equation modeling highlights the potential of Kim-1 as a biomarker for chronic kidney disease. 22269876

2012

Entrez Id: 6469
Gene Symbol: SHH
SHH
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Sonic hedgehog is a novel tubule-derived growth factor for interstitial fibroblasts after kidney injury. 24744439

2014

Entrez Id: 632
Gene Symbol: BGLAP
BGLAP
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.210 Biomarker RGD Serum osteocalcin and to a lesser extend tartrate-resistant acid phosphatase and urinary pyridinoline and deoxypyridinoline crosslinks were higher in the CRF animals compared to the shams, particularly in the animals of the HPD group with more pronounced CRF. 17365904

2007

Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 Therapeutic RGD Sedentary CRF rats exhibited azotemia, hypertension, anemia, oxidative stress, activation of NF-kappaB and upregulations of reactive oxygen species-generating enzyme, NAD(P)H oxidase, MCP-1, cyclooxygenase-2 (COX-2), and PAI-1 in LV. 18797164

2009

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.300 SusceptibilityMutation RGD Role of Nitric Oxide Pathway in Development and Progression of Chronic Kidney Disease in Rats Sensitive and Resistant to its Occurrence in an Experimental Model of 5/6 Nephrectomy. 29018182

2017

Entrez Id: 1234
Gene Symbol: CCR5
CCR5
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.260 Biomarker RGD Role of FTY720 on M1 and M2 macrophages, lymphocytes, and chemokines in 5/6 nephrectomized rats. 19535570

2009

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.220 Biomarker RGD Role of FTY720 on M1 and M2 macrophages, lymphocytes, and chemokines in 5/6 nephrectomized rats. 19535570

2009

Entrez Id: 1536
Gene Symbol: CYBB
CYBB
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.510 Biomarker RGD Renal tissue abundance of gp91(phox) subunit of NAD(P)H oxidase was elevated in the untreated CRF group and was partially reduced in the iron dextran-treated CRF group. 15550752

2005

Entrez Id: 1906
Gene Symbol: EDN1
EDN1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.250 Biomarker RGD Renal endothelin gene expression is increased in remnant kidney and correlates with disease progression. 8441230

1993

Entrez Id: 1644
Gene Symbol: DDC
DDC
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.200 Biomarker RGD Renal dopaminergic system activity in rat remnant kidney up to twenty-six weeks after surgery. 19167406

2009